¿Podrían las lectinas ayudar a explicar por qué quienes comen más frijoles y granos integrales tienen menos cáncer?
Las lectinas son las culpables del gran «incidente del frijol blanco» de 2006 en Japón. Un sábado por la noche, un programa de televisión presentó un nuevo método para perder peso. El método era simple: tostar algunos frijoles blancos secos, crudos en una sartén durante tres minutos, moler los frijoles hasta convertirlos en polvo y luego espolvorearlos sobre el arroz. En cuestión de días, mil personas enfermaron, algunas con diarrea y vómitos tan severos que terminaron en el hospital. ¿Por qué? Intoxicación con lectina. Tres minutos de calor seco no son suficientes para destruir las lectinas tóxicas de los frijoles. Si no los sumerge previamente, debe hervir frijoles grandes durante una hora completa para destruir por completo todas las lectinas, aunque si primero los sumerge durante la noche, el 98 por ciento de las lectinas desaparecen después de hervir durante solo 15 minutos y todas desaparecen. en media hora, como puede ver a las 0:44 en mi video ¿Son buenas o malas las lectinas en la comida? Y, de hecho, cuando los investigadores probaron los frijoles blancos, descubrieron que tostarlos durante tres minutos no sirvió de nada. No es de extrañar que la gente se enfermara. Pero, el 95 por ciento de las lectinas se inactivó después de hervirlas durante tres minutos y se inactivó por completo después de diez minutos de ebullición. Evidentemente, «‘No comer frijoles crudos’ es una advertencia tradicional en Japón para prevenir problemas intestinales», y ahora sabemos por qué.
Si bien el enlatado puede eliminar por completo las lectinas de la mayoría de los frijoles enlatados, es posible que quede algo de actividad residual de lectina en los frijoles enlatados, aunque aparentemente no lo suficiente como para provocar toxicidad. E, irónicamente, «cómo las dosis de lectinas pueden ser beneficiosas al estimular la función intestinal, limitar el crecimiento tumoral y mejorar la obesidad». ¿Qué? Pensé que las lectinas eran tóxicas.
Posteriormente, se descubrió que las lectinas no solo podían distinguir entre los dos tipos de células, sino que también podían extinguir las células cancerosas, dejando en gran medida las células normales en paz. Por ejemplo, se descubrió que esa misma lectina de frijol blanco suprime casi por completo el crecimiento de células cancerosas de cabeza y cuello humanos, células de cáncer de hígado, células de cáncer de mama y células de cáncer de cuello uterino (al menos la mayor parte del camino), en aproximadamente tres días, pero eso fue en una placa de Petri. Estos estudios en placas de Petri son en gran parte la base de la evidencia de la actividad antitumoral de las lectinas vegetales. ¿Cómo sabemos siquiera que nuestro cuerpo absorbe las lectinas de la dieta?
El cáncer colorrectal es una cosa. El hecho de que las lectinas pueden matar las células cancerosas de colon en una placa de Petri puede ser aplicable, ya que las lectinas que ingerimos pueden entrar en contacto directo con células cancerosas o precancerosas en nuestro colon, «proporcionando un mecanismo» por el cual el consumo de frijoles puede ayudar en «la prevención y tratamiento del cáncer colorrectal ”. Aún más emocionante es el potencial para rehabilitar eficazmente las células cancerosas. La «pérdida de diferenciación y la invasión son las características histológicas de las células malignas», lo que significa que cuando una célula normal se transforma en una célula cancerosa, tiende a perder su función especializada. Las células cancerosas de mama se vuelven menos parecidas a las mamas y las células cancerosas de colon se vuelven menos parecidas a las del colon. Lo que estos investigadores demostraron, por primera vez, es que la lectina de las habas podría tomar células de cáncer de colon y convertirlas en células normales. Como puede ver en 4:13 en mi video, antes de la exposición a las lectinas de habas, las células cancerosas crecían en grupos amorfos. Pero, después de la exposición a las lectinas de las habas durante dos semanas, esas mismas células cancerosas comenzaron a volver a crecer en estructuras glandulares como un problema normal del colon. Por lo tanto, las lectinas en la dieta o ponerlas en una pastilla «pueden retrasar la progresión del cáncer de colon», lo que podría ayudar a explicar por qué el consumo dietético de frijoles, guisantes, garbanzos y lentejas parece reducir el riesgo de cáncer colorrectal según 14 estudios que involucran casi dos millones de participantes. Bien, pero ¿qué pasa con los cánceres fuera del tracto digestivo?
En términos de fitoquímicos en la lucha contra el cáncer, las lectinas son capaces de «resistir la digestión, lo que da como resultado una alta biodisponibilidad», lo que potencialmente permite que «los mecanismos celulares del huésped utilicen todo el potencial de los … beneficios dramáticos contra el cáncer» que las lectinas tienen para ofrecer. . Pero estos dramáticos beneficios aún no se han demostrado en las personas. Sin embargo, sí sabemos que los estudios de población muestran «que el consumo de una dieta a base de plantas está fuertemente asociado con un riesgo reducido de desarrollar ciertos tipos de cáncer». Las personas que consumen una dieta a base de plantas podrían estar consumiendo menos carcinógenos, pero las plantas tienen todos esos componentes activos que parecen proteger contra la «iniciación, promoción o progresión» del cáncer. Entonces, tal vez las lectinas sean uno de esos compuestos protectores. Sabemos que las personas que comen más frijoles y granos integrales tienden a tener menos cáncer en general, pero no estamos seguros exactamente por qué. Ahora, podría decir: «¿A quién le importa por qué?» Bueno, a Big Pharma le importa. No puede ganar tanto dinero con alimentos saludables como con «medicamentos a base de lectina».
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