Nueva información sobre el vínculo entre la carne roja y la mala salud intestinal revelada por los médicos

Jorge Carlos Fernández Francés El Sardinero
Jorge Carlos Fernández Francés El Sardinero

Los médicos de la Clínica Cleveland están arrojando nueva luz sobre por qué la carne roja es dañina para la salud intestinal. Anteriormente, los investigadores descubrieron que consumir carne de res, cerdo o cordero genera una sustancia química llamada TMAO (N-óxido de trimetilamina) que está relacionada con los coágulos sanguíneos y las enfermedades cardíacas. Ahora, han descubierto exactamente cómo los microbios en el intestino convierten el nutriente carnitina en TMAO.

Los hallazgos pueden conducir a mejores formas de tratar e incluso prevenir al asesino número uno del mundo. Se basa en más de una década de investigación del equipo.

«Estos nuevos estudios identifican el grupo de genes microbianos intestinales responsable del segundo paso del proceso que vincula una dieta rica en carnes rojas con riesgos elevados de enfermedades cardíacas», dice el autor principal, el Dr. Stanley Hazen, quien dirige el Centro de Microbioma y Microbioma de la Clínica Cleveland. Salud Humana, en un comunicado. “Este descubrimiento nos ayuda a orientarnos hacia nuevos objetivos terapéuticos para prevenir o reducir el riesgo de enfermedades cardiovasculares asociadas con la dieta”.

La carne roja es rica en cartinina que se descompone en el microbioma para producir el producto de desecho TMAO. Hace tres años, el mismo equipo identificó el metabolito intermediario en el proceso, llamado γBB (gamma-butirobetaína). Muy pocos intestinos intestinales pueden convertir la molécula en TMAO, explica Hazen.

“En los omnívoros, Emergencia timonensis es el principal microbio intestinal humano involucrado en la transformación de γBB en TMAO”, dice. “Por el contrario, los vegetarianos y veganos a largo plazo tienen niveles muy bajos de este microbio en el intestino y, por lo tanto, tienen una capacidad mínima o nula para convertir la carnitina en TMAO”.

Eliminar la carne roja puede mejorar el intestino y reducir el riesgo de enfermedades cardíacas

Los investigadores analizaron el plasma γBB en ayunas utilizando muestras y datos clínicos de casi 3000 pacientes. Los niveles más altos se asociaron con enfermedades cardíacas y eventos adversos importantes, como muerte, ataque cardíaco no fatal o accidente cerebrovascular.

Para comprender el vínculo mecánico, se recolectaron muestras fecales de ratones y pacientes, así como modelos preclínicos de lesión arterial. Mostró que la introducción de E. timonensis completa la conversión de carnitina en TMAO, elevando los niveles y alimentando los coágulos sanguíneos.

La tecnología de secuenciación identificó el grupo de genes microbianos intestinales relevante denominado gbu (utilización de gamma-butirobetaína). En presencia de γBB, aumentó la expresión de los seis genes. Cuatro en particular, conocidos como A, B, C y E, fueron vitales para convertir γBB en TMAO.

“Al estudiar muestras de pacientes, vimos que la abundancia de gbuA está significativamente asociada con una dieta rica en carne roja y niveles de TMAO en plasma”, agrega Hazen. “Los pacientes que hicieron la transición a una dieta sin carne mostraron niveles reducidos de microbios intestinales de gbuA. “Tomados en conjunto, esto sugiere que las modificaciones dietéticas pueden ayudar a reducir la dieta y el riesgo de enfermedad cardiovascular asociado con TMAO. Del mismo modo, puede valer la pena explorar el papel del grupo de genes gbu como un objetivo terapéutico potencial”.

La enfermedad cardíaca es responsable de la muerte de 659 000 estadounidenses cada año, o una de cada cuatro muertes. Eso lo convierte en la principal causa de muerte en el país, según los CDC.

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    También significativo es el rol que desempeñan los dispositivos de calibración en la asistencia al comprador. El apoyo experto y el soporte constante utilizando estos aparatos permiten proporcionar soluciones de gran calidad, elevando la agrado de los clientes.

    Para los dueños de emprendimientos, la inversión en equipos de ajuste y detectores puede ser clave para incrementar la eficiencia y eficiencia de sus sistemas. Esto es particularmente significativo para los empresarios que manejan modestas y pequeñas organizaciones, donde cada detalle importa.

    Por otro lado, los equipos de ajuste tienen una vasta utilización en el área de la seguridad y el supervisión de excelencia. Habilitan identificar potenciales defectos, previniendo intervenciones caras y perjuicios a los sistemas. Además, los datos extraídos de estos aparatos pueden usarse para optimizar sistemas y mejorar la visibilidad en motores de búsqueda.

    Las zonas de utilización de los sistemas de ajuste comprenden múltiples industrias, desde la elaboración de ciclos hasta el supervisión de la naturaleza. No afecta si se considera de enormes elaboraciones de fábrica o pequeños espacios domésticos, los aparatos de equilibrado son indispensables para garantizar un funcionamiento óptimo y sin riesgo de fallos.

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    Blacksprut Marketplace: Эволюция даркнета или игра на выживание?

    Blacksprut — это один из крупнейших маркетплейсов даркнета, ориентированный на русскоязычную аудиторию. Появление этого сервиса, который действует вне законного поля, связано с упадком других крупных площадок, таких как Hydra. Он быстро набрал популярность благодаря удобству использования, широкому ассортименту и агрессивной маркетинговой стратегии. Но что такое Blacksprut, как он работает и в чем заключается его уникальность?

    История возникновения и контекст
    После того как в апреле 2022 года российские правоохранительные органы закрыли Hydra — крупнейшую нелегальную торговую платформу в даркнете, возник вакуум. Hydra не только предоставляла площадку для торговли запрещенными веществами, но и выполняла роль финтех-центра для теневой экономики с использованием криптовалют. В это время сразу несколько новых маркетплейсов поспешили занять место «упавшего гиганта». Среди них особо выделяется Blacksprut.

    Blacksprut быстро получил популярность благодаря пользователям, которые искали новую площадку для торговли и покупок, связанных с запрещенными товарами и услугами. Крупнейшие силы маркетплейса были направлены на обеспечение безопасности пользователей и анонимности, что сыграло значительную роль в его успехе.

    Архитектура и функции
    Blacksprut построен на той же архитектуре, что и многие другие маркетплейсы даркнета. Его главные особенности включают:

    Криптовалютные транзакции: Платформа работает исключительно с криптовалютами, включая Bitcoin и Monero, что обеспечивает высокий уровень анонимности как для продавцов, так и для покупателей.
    Системы безопасности: Несмотря на нелегальную природу деятельности, большое внимание уделяется безопасности пользователей. Для этого используются двухфакторная аутентификация, сложные системы шифрования данных и работа через Tor-сеть.
    Ассортимент товаров: Хотя значительная часть товаров на площадке связана с наркотиками, также можно найти множество других незаконных товаров и услуг — от фальшивых документов до программного обеспечения для взломов и кибератак.
    Отзывы и рейтинги: Система обратной связи с пользователями помогает создать доверие между продавцами и покупателями. Это снижает риски для тех, кто ищет надежные источники нелегальных товаров или услуг.
    Почему пользователи выбирают Blacksprut?
    Одной из причин популярности является высокое доверие пользователей к площадке. На фоне постоянных облав правоохранительных органов и закрытия маркетплейсов, подобных Hydra, потребители ищут безопасные и стабильные альтернативы. Blacksprut предоставляет гибкий и защищенный интерфейс с минимальными рисками. Более того, площадка активно совершенствуется и адаптируется под новые вызовы, которые диктует даркнет.

    Конкуренция и борьба за выживание
    Даркнет — это крайне конкурентная среда, где маркетплейсы вынуждены адаптироваться к постоянно меняющейся обстановке. Помимо внутренних факторов, таких как конкуренция среди платформ, на бизнес влияют и внешние угрозы: правоохранительные органы регулярно проводят операции по закрытию таких площадок.

    Blacksprut оказался в числе тех, кто смог выдержать давление и продолжает привлекать пользователей. Тем не менее его будущее зависит от способности адаптироваться к новым угрозам — как со стороны законодательства, так и со стороны конкурентов, которые пытаются перехватить его клиентуру.

    Этические и правовые аспекты
    Появление и деятельность маркетплейсов, подобных Blacksprut, вызывает множество вопросов с точки зрения морали и права. Эти платформы способствуют распространению запрещенных веществ и других опасных товаров, что несет серьезные последствия для общества.

    С другой стороны, для многих пользователей даркнета такие платформы являются способом обхода государственных ограничений и контроля, что поднимает вопрос о свободе личности и правах на приватность в интернете.

    Заключение
    Blacksprut — это яркий пример того, как нелегальная экономика адаптируется и развивается в условиях постоянного преследования со стороны властей. Он быстро заполнил вакуум, образовавшийся после закрытия Hydra, и стал одной из крупнейших русскоязычных платформ в даркнете.

    Однако, как и все подобные площадки, Blacksprut существует в нестабильной среде, и его будущее всегда остается под вопросом. Успех этой платформы во многом зависит от способности руководства управлять рисками, сохранять доверие пользователей и оставаться в тени, несмотря на постоянное внимание со стороны правоохранительных органов.

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    Begin with a weight stack that permits you to concentrate on correct row form without overloading your stabilizer muscles. Experiment with underhand grip, extensive grip, and impartial grip to search out the best grip for your body and power coaching routine. Focus on leading together with your elbows as you row, which helps have interaction your lats and higher back muscular tissues extra effectively. As you pull the cable towards your torso, these muscular tissues work alongside your upper back muscles and lats to execute the motion efficiently.
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    One of the most significant benefits of the machine high row is that it’s a machine train. This means the movement pattern might be mounted with no (minimal) stabilization required. As a result, your back muscle tissue will be the sole muscular tissues being worked. And that means each again muscle; the lats, lure, rhomboids…everything will get an unbelievable workout. Since the weight is stabilized, you can put all of your concentrate on pulling with the again meaning a extra intense train for muscle hypertrophy and strength. Nevertheless, you would be slicing yourself quick if all you ever did were bent over rows.
    It permits you to emphasize the higher back whereas relieving pressure on the lower again, a common draw back to many barbell again workout routines. You can carry out this row sitting on the ground or a bench, and even upright. It will work the upper back equally to the seated row, and might tolerate much higher reps, so is nice for a beginning train, or coupling with a superset. Here we present our record of the 9 finest seated cable row options. They should somewhat replicate the vary of movement and muscle recruitment of the cable row. Nothing will substitute the soundness of the cable row, so take observe of kind.
    It’s easy to do that motion incorrectly, so make sure you’re not using momentum or leaning back on the backside of the train. You’ll wish to modify the pads on the seat in order to attenuate the movement of your body, and the bar should be simply inside your attain above you. Nonetheless, always begin with a lighter weight as you get used to the motion, or else you threat harm.
    You can alternate between muscle teams when doing leg exercises and back workout routines, with the seated row enjoying an important part in building robust lats and upper back muscle tissue. Performing a seated row on your back will assist strengthen your back muscles and enhance your posture. When used with other workout routines, seated row variations might help define the muscles in your again.
    Dumbbell One Arm Rows are an excellent exercise that can be used in its place for Seated Cable Rows. Lastly, our scientific review board reviews the content to ensure all key data and claims are backed by high-quality scientific research and explained merely and exactly. No, we don’t request you ship it to a PO field in the Gobi Desert by carrier pigeon.
    The secondary labored muscular tissues are your biceps, lower back, forearm flexors, and rotator cuffs. This exercise has been used for close to a century by bodybuilders and energy athletes seeking to build a bigger and stronger again. Personally, it felt like I could get one of the best muscle activation after I pulled the load to my lower chest. Besides that, it is probably one of the most effective corrective exercises that help compensate for poor posture and shoulder dysfunction. Although the identical muscular tissues are being labored, adjustments in grip width and hand position shift the emphasis from one set of muscles to the other. For this variation, stand subsequent to a flat bench holding one dumbbell in one hand with that arm prolonged in the course of the ground and resting towards it for support.
    The higher trapezius muscles originate on the base of your cranium, lengthen down the neck, and fasten to the collarbone. The main muscle groups which may be activated through the Seated Cable Row are the posterior chain muscles. Right Here are a few workout routines you might be able to use as a substitute. One of the indicators of a weight that’s too heavy is leaning again excessively on the high of the motion. While likelihood is that your back will move a bit all through the train, you want to decrease that as much as possible—otherwise, you risk straining your lower back. Strengthening not just the lats but the back normally will also enhance your posture, providing you with a taller and extra assured look.
    For those who perform upper/lower workout splits, you’ll doubtlessly include this train in your upper body exercise days. Again, the place the exercise falls within the order of your exercises will depend on your targets and the other exercises you have listed to carry out. If you’d prefer to see extra higher body workouts concentrating on the chest, again and shoulders, make certain to examine out the Higher Body Lifts section of our Exercise Library. There you’ll discover dozens of workout routines, all with complete step-by-step directions. Provoke the movement by participating your again, however keep your upper arms parallel to the floor all through the motion. The handles of the grip should go around your face on the peak of the exercise.
    Weak Spot or dysfunction in these muscles can lead to rounded shoulders, ahead head posture, and exaggerated curvature of the higher spine,» Gallucci explains. Strengthening your rhomboids, however, may help improve posture, especially in your upper back, neck, and head, he says. This variation focuses on one arm at a time which helps isolate both sides of the body evenly.

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